Wani bincike-bincike da aka buga a cikin Magungunan Ciki ya nuna cewa maganin rigakafi da tsarin glucocorticoids suna da alaƙa da ƙarancin gazawar jiyya a cikin manya tare da.COPDexacerbations idan aka kwatanta da placebo ko babu magani sa baki.

Domin gudanar da wani tsari bita da meta-bincike, Claudia C. Dobler, MD, Bond University, Australia, da sauransu kimanta 68 bazuwar gwajin gwaji, ciki har da 10,758 manya marasa lafiya da m exacerbations naCOPDwadanda aka yi musu jinya a asibiti ko marasa lafiya.Binciken ya kwatanta magungunan magunguna tare da placebo, kulawa na yau da kullum ko wasu magunguna.

Amfanin maganin rigakafi da tsarin glucocorticoids

A cikin kwatancen binciken na kwanaki 7-10 na maganin rigakafi na tsarin da placebo ko kulawa na al'ada ga marasa lafiya na marasa lafiya ko marasa lafiya, a ƙarshen jiyya, maganin rigakafi yana da alaƙa da kawar da mummunar cutar da cutar, amma ba su da alaƙa da tsananin rashin ƙarfi da yanayin jiyya (OR = 2.03; 95% CI, 1.47- -2.8; matsakaicin ingancin shaida).Bayan ƙarshen maganin warkewa, a cikin nazarin marasa lafiya tare da ƙananan ƙananan ƙananan ƙwayoyin cuta, tsarin maganin rigakafi na tsarin zai iya rage yawan raunin jiyya (OR = 0.54; 95% CI, 0.34-0.86; matsakaicin ƙarfin shaida).Marasa lafiya da marasa lafiya masu sauƙi zuwa matsakaita ko matsakaita zuwa tsanani mai tsanani, maganin rigakafi kuma na iya rage wahalar numfashi, tari da sauran alamun.

Hakazalika, ga marasa lafiya da marasa lafiya, ana kwatanta tsarin glucocorticoids tare da placebo ko kulawa na al'ada.Bayan kwanaki 9-56 na jiyya, tsarin glucocorticoids na tsarin ba zai iya kasa kasawa ba (OR = 0.01; 95% CI, 0-0.13; ingancin shaidar yana da ƙasa), ba tare da la'akari da yanayin jiyya ko matsayi mai tsanani ba.A ƙarshen kwanaki 7-9 na jiyya, marasa lafiya da ke da rauni mai sauƙi zuwa mai tsanani a cikin asibiti na asibiti da kuma asibiti sun sami sauƙi na dyspnea.Duk da haka, tsarin glucocorticoids na tsarin yana hade da karuwa a cikin adadin jimlar da kuma abubuwan da suka shafi endocrin.

Masu bincike sun yi imanin cewa bisa ga bincikensu, likitoci da abokan aiki ya kamata a tabbatar da cewa ya kamata a yi amfani da maganin rigakafi da kuma glucocorticoids na tsarin a duk wani mummunan tashin hankali.COPD(ko da mai laushi ne).A nan gaba, za su iya mafi kyawun sanin waɗanne marasa lafiya za su fi amfana daga waɗannan jiyya kuma waɗanda marasa lafiya ba za su amfana ba (bisa ga masu nazarin halittu, ciki har da furotin C-reactive ko procalcitonin, eosinophils na jini).

Bukatar ƙarin shaida

A cewar masu binciken, akwai rashin cikakkun bayanai game da fifikon maganin rigakafi ko maganin glucocorticoid, da kuma shaidar yin amfani da wasu magunguna, ciki har da aminophylline, magnesium sulfate, magungunan hana kumburi, corticosteroids inhaled, da bronchodilators na gajere.

Mai binciken ta ce za ta hana likitoci yin amfani da magungunan da ba a tabbatar da su ba, kamar aminophylline da magnesium sulfate.Masu bincike sun yi imanin cewa ko da yake akwai bincike da yawa akan COPD, yawancin kwayoyi don magance mummunan cututtuka na COPD ba su da isasshen shaida.Alal misali, a cikin aikin asibiti, muna amfani da bronchodilators na gajeren lokaci don kawar da dyspnea a lokacin mummunan cututtuka na COPD.Waɗannan sun haɗa da antagonists masu karɓa na muscarin na ɗan gajeren aiki (ipratropium bromide) da agonists masu karɓar beta na gajeriyar aiki (salbutamol).

Baya ga bincike mai inganci, ingantaccen bincike kan jiyya na miyagun ƙwayoyi, masu binciken sun kuma nuna cewa sauran nau'ikan tsoma baki na iya cancanci yin nazari.

"Shaidu masu girma suna nuna cewa wasu hanyoyin kwantar da hankali ba tare da magunguna ba, musamman ma wadanda suka fara motsa jiki a farkon lokacin tashin hankali, na iya inganta matsananciyar matsananciyar matsananciyar cututtuka na COPD marasa lafiya a asibiti.The American Thoracic Society / European Respiratory Conference a cikin 2017 Sharuɗɗan da aka bayar sun haɗa da shawarwarin sharuɗɗa (ƙananan shaidar shaida) a lokacin asibiti na mummunan cututtuka na COPD, kada ku fara farfadowa na huhu, amma wasu sababbin shaida sun fito tun daga lokacin cewa muna buƙatar da yawa high quality-shaida na farkon motsa jiki a lokacin m exacerbation na COPD don Tabbatar da tasiri na farko motsa jiki ga m exacerbation na COPD.